Drug interactions
Ramelteon + Somatropin
Severity: Minor
Ramelteon and Somatropin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase the activity of some CYP enzymes, possibly including CYP1A2, which is the main enzyme metabolizing ramelteon. Lower ramelteon exposure and reduced effect are theoretically possible. Clinical data specific to ramelteon are lacking.
What this interaction means in plain words
Ramelteon and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ramelteon belongs to Central Nervous System; Somatropin belongs to Endocrine.
Why it happens
Possible induction of CYP1A2 by somatropin, increasing ramelteon clearance; this is not well established.
What to do
No empirical dose change is needed. Watch for reduced hypnotic response and adjust therapy if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Ramelteon with Somatropin?
MediHelp rates the interaction as minor. Ramelteon and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase the activity of some CYP enzymes, possibly including CYP1A2, which is the main enzyme metabolizing ramelteon. Lower ramelteon exposure and reduced effect are theoretically possible. Clinical data specific to ramelteon are lacking.
How serious is the interaction between Ramelteon and Somatropin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Watch for reduced hypnotic response and adjust therapy if it occurs.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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