Drug interactions
Ramelteon + Sufentanil sl
Severity: Moderate
Ramelteon and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with other sedating drugs can produce additive CNS depression, including profound sedation and slowed breathing. Ramelteon has relatively mild sedative effects, but the opioid class warning for sedative combinations still applies.
What this interaction means in plain words
Ramelteon and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression through pharmacodynamic synergy.
What to do
Use the lowest effective doses for the shortest duration and monitor for sedation and respiratory depression. Counsel patients and caregivers about warning signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Ramelteon with Sufentanil sl?
MediHelp rates the interaction as moderate. Ramelteon and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids combined with other sedating drugs can produce additive CNS depression, including profound sedation and slowed breathing. Ramelteon has relatively mild sedative effects, but the opioid class warning for sedative combinations still applies.
How serious is the interaction between Ramelteon and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and monitor for sedation and respiratory depression. Counsel patients and caregivers about warning signs.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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