Drug interactions
Ramelteon + Triazolam
Severity: Moderate
Ramelteon and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together these hypnotics may increase sedation, psychomotor impairment and the risk of falls or complex sleep behaviors. Dual hypnotic therapy generally offers little benefit.
What this interaction means in plain words
Ramelteon and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via melatonin receptor agonism and GABA-A enhancement.
What to do
Avoid concurrent use where possible and use the lowest effective doses if needed. Monitor for next-day impairment, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Ramelteon with Triazolam?
MediHelp rates the interaction as moderate. Ramelteon and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Together these hypnotics may increase sedation, psychomotor impairment and the risk of falls or complex sleep behaviors. Dual hypnotic therapy generally offers little benefit.
How serious is the interaction between Ramelteon and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and use the lowest effective doses if needed. Monitor for next-day impairment, especially in older adults.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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