Drug interactions
Ramelteon + Trifluoperazine
Severity: Moderate
Ramelteon and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine is an antipsychotic that can cause sedation, and combining it with ramelteon may modestly increase drowsiness. It is a less sedating phenothiazine, so the effect is usually manageable.
What this interaction means in plain words
Ramelteon and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excess drowsiness and counsel about driving and hazardous tasks. Reduce the dose of one agent if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Ramelteon with Trifluoperazine?
MediHelp rates the interaction as moderate. Ramelteon and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine is an antipsychotic that can cause sedation, and combining it with ramelteon may modestly increase drowsiness. It is a less sedating phenothiazine, so the effect is usually manageable.
How serious is the interaction between Ramelteon and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess drowsiness and counsel about driving and hazardous tasks. Reduce the dose of one agent if sedation is troublesome.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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