Drug interactions
Ramelteon + Valerian
Severity: Minor
Ramelteon and Valerian: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valerian is an herbal sedative that may add to the sleep-promoting and drowsy effects of ramelteon. This may cause excessive sedation or reduced alertness the next day.
What this interaction means in plain words
Ramelteon and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive sedative effects; valerian acts on GABAergic pathways while ramelteon acts on melatonin receptors.
What to do
Avoid taking both together unless advised, and counsel on next-day drowsiness. Stop valerian if excess sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Ramelteon with Valerian?
MediHelp rates the interaction as minor. Ramelteon and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valerian is an herbal sedative that may add to the sleep-promoting and drowsy effects of ramelteon. This may cause excessive sedation or reduced alertness the next day.
How serious is the interaction between Ramelteon and Valerian?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking both together unless advised, and counsel on next-day drowsiness. Stop valerian if excess sedation occurs.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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