Drug interactions
Rapacuronium + Verapamil
Severity: Moderate
Rapacuronium and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can potentiate non-depolarizing neuromuscular blockers, prolonging paralysis and delaying recovery. Rapacuronium has been withdrawn from the market.
What this interaction means in plain words
Rapacuronium and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced presynaptic acetylcholine release and postsynaptic effects of calcium channel blockade enhancing neuromuscular blockade.
What to do
Monitor neuromuscular function with a nerve stimulator and reduce the blocker dose; be prepared for prolonged ventilatory support.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Rapacuronium with Verapamil?
MediHelp rates the interaction as moderate. Rapacuronium and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium channel blockers can potentiate non-depolarizing neuromuscular blockers, prolonging paralysis and delaying recovery. Rapacuronium has been withdrawn from the market.
How serious is the interaction between Rapacuronium and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a nerve stimulator and reduce the blocker dose; be prepared for prolonged ventilatory support.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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