Drug interactions
Rasagiline + Selegiline
Severity: Contraindicated
Rasagiline and Selegiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are MAO-B inhibitors, and combined use increases loss of MAO selectivity. This raises the risk of hypertensive crisis and serotonin syndrome without added benefit.
What this interaction means in plain words
Rasagiline and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Rasagiline belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Duplicate MAO inhibition causing excess monoamine accumulation.
What to do
Do not use together; allow a 14-day washout when switching between them.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Rasagiline with Selegiline?
MediHelp rates the interaction as contraindicated. Rasagiline and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are MAO-B inhibitors, and combined use increases loss of MAO selectivity. This raises the risk of hypertensive crisis and serotonin syndrome without added benefit.
How serious is the interaction between Rasagiline and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; allow a 14-day washout when switching between them.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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