Drug interactions
Regorafenib + Saquinavir
Severity: Major
Regorafenib and Saquinavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir inhibits CYP3A4 and may increase regorafenib exposure while reducing active metabolites M-2 and M-5. The overall effect on toxicity and efficacy is uncertain.
What this interaction means in plain words
Regorafenib and Saquinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4 reduces regorafenib metabolism and alters metabolite formation.
What to do
Avoid the combination and choose an alternative antiretroviral. If unavoidable, monitor liver function and for adverse reactions such as hypertension and skin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Regorafenib
Frequently asked questions
Can I take Regorafenib with Saquinavir?
MediHelp rates the interaction as major. Regorafenib and Saquinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Saquinavir inhibits CYP3A4 and may increase regorafenib exposure while reducing active metabolites M-2 and M-5. The overall effect on toxicity and efficacy is uncertain.
How serious is the interaction between Regorafenib and Saquinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antiretroviral. If unavoidable, monitor liver function and for adverse reactions such as hypertension and skin toxicity.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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