Drug interactions
Regorafenib + Sofosbuvir / velpatasvir
Severity: Moderate
Regorafenib and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit BCRP and increase exposure to sofosbuvir and velpatasvir. The clinical significance is uncertain.
What this interaction means in plain words
Regorafenib and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Regorafenib inhibits BCRP and P-gp efflux of sofosbuvir and velpatasvir.
What to do
Monitor for antiviral adverse effects and liver function. No empiric dose change is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Frequently asked questions
Can I take Regorafenib with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Regorafenib and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib may inhibit BCRP and increase exposure to sofosbuvir and velpatasvir. The clinical significance is uncertain.
How serious is the interaction between Regorafenib and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for antiviral adverse effects and liver function. No empiric dose change is established.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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