Drug interactions
Regorafenib + Sulfasalazine
Severity: Moderate
Regorafenib and Sulfasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit BCRP, and sulfasalazine is a sensitive BCRP substrate. Systemic sulfasalazine exposure may increase, raising the risk of its adverse effects.
What this interaction means in plain words
Regorafenib and Sulfasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Regorafenib inhibits intestinal and hepatic BCRP, reducing efflux of sulfasalazine.
What to do
Monitor for sulfasalazine adverse effects, including blood count changes and liver enzyme elevation. Consider a lower sulfasalazine dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Frequently asked questions
Can I take Regorafenib with Sulfasalazine?
MediHelp rates the interaction as moderate. Regorafenib and Sulfasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib may inhibit BCRP, and sulfasalazine is a sensitive BCRP substrate. Systemic sulfasalazine exposure may increase, raising the risk of its adverse effects.
How serious is the interaction between Regorafenib and Sulfasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sulfasalazine adverse effects, including blood count changes and liver enzyme elevation. Consider a lower sulfasalazine dose if toxicity occurs.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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