Drug interactions
Regorafenib + Tenofovir af
Severity: Minor
Regorafenib and Tenofovir af: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit BCRP and P-gp, potentially increasing tenofovir alafenamide absorption. The effect is likely small given the low dose of tenofovir alafenamide.
What this interaction means in plain words
Regorafenib and Tenofovir af have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Regorafenib inhibits intestinal BCRP/P-gp efflux, increasing tenofovir alafenamide absorption.
What to do
No dose adjustment is expected. Monitor renal function and liver tests periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Regorafenib
Frequently asked questions
Can I take Regorafenib with Tenofovir af?
MediHelp rates the interaction as minor. Regorafenib and Tenofovir af have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Regorafenib may inhibit BCRP and P-gp, potentially increasing tenofovir alafenamide absorption. The effect is likely small given the low dose of tenofovir alafenamide.
How serious is the interaction between Regorafenib and Tenofovir af?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is expected. Monitor renal function and liver tests periodically.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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