Drug interactions
Regorafenib + Tenofovir df
Severity: Minor
Regorafenib and Tenofovir df: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit the efflux transporter BCRP in the gut and elsewhere. Tenofovir exposure could rise slightly, though the clinical relevance is uncertain since tenofovir disposition depends mainly on renal OAT and MRP transporters.
What this interaction means in plain words
Regorafenib and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of BCRP (ABCG2) transport by regorafenib, which may modestly increase substrate exposure.
What to do
No routine adjustment is needed; monitor renal function and tenofovir-related adverse effects during combined therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Regorafenib
Frequently asked questions
Can I take Regorafenib with Tenofovir df?
MediHelp rates the interaction as minor. Regorafenib and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Regorafenib may inhibit the efflux transporter BCRP in the gut and elsewhere. Tenofovir exposure could rise slightly, though the clinical relevance is uncertain since tenofovir disposition depends mainly on renal OAT and MRP transporters.
How serious is the interaction between Regorafenib and Tenofovir df?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor renal function and tenofovir-related adverse effects during combined therapy.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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