Drug interactions
Regorafenib + Tenofovir disoproxil
Severity: Minor
Regorafenib and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit the efflux transporter BCRP, which could modestly raise exposure to BCRP substrates. Tenofovir is mainly renally eliminated and BCRP is a minor contributor, so any clinically relevant effect is unlikely.
What this interaction means in plain words
Regorafenib and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible BCRP inhibition by regorafenib; the contribution of BCRP to tenofovir disposition is small and the effect is predicted rather than demonstrated.
What to do
No dose change is normally needed. Monitor renal function per usual tenofovir practice.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Regorafenib
Frequently asked questions
Can I take Regorafenib with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Regorafenib and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Regorafenib may inhibit the efflux transporter BCRP, which could modestly raise exposure to BCRP substrates. Tenofovir is mainly renally eliminated and BCRP is a minor contributor, so any clinically relevant effect is unlikely.
How serious is the interaction between Regorafenib and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed. Monitor renal function per usual tenofovir practice.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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