Drug interactions
Reishi + Sulindac
Severity: Minor
Reishi and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reishi mushroom has reported antiplatelet activity that could theoretically add to the bleeding tendency of sulindac. Clinical evidence is limited.
What this interaction means in plain words
Reishi and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive inhibition of platelet aggregation by reishi constituents; not well characterized.
What to do
Advise patients to report bruising or bleeding and consider avoiding reishi if other antithrombotic agents are also used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Reishi with Sulindac?
MediHelp rates the interaction as minor. Reishi and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reishi mushroom has reported antiplatelet activity that could theoretically add to the bleeding tendency of sulindac. Clinical evidence is limited.
How serious is the interaction between Reishi and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report bruising or bleeding and consider avoiding reishi if other antithrombotic agents are also used.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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