Drug interactions
Relugolix + Rifampicin
Severity: Major
Relugolix and Rifampicin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin induces both P-glycoprotein and CYP3A and lowers relugolix exposure. This may reduce suppression of testosterone or estrogen-related effects and weaken efficacy.
What this interaction means in plain words
Relugolix and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Relugolix belongs to Endocrine; Rifampicin belongs to Anti Bacterial.
Why it happens
Combined P-gp and CYP3A induction by rifampicin increases relugolix efflux and metabolism, reducing its systemic exposure.
What to do
Avoid the combination where possible and use an alternative antimycobacterial. If rifampicin is essential, increase the relugolix dose as directed in labeling and monitor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Relugolix with Rifampicin?
MediHelp rates the interaction as major. Relugolix and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin induces both P-glycoprotein and CYP3A and lowers relugolix exposure. This may reduce suppression of testosterone or estrogen-related effects and weaken efficacy.
How serious is the interaction between Relugolix and Rifampicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative antimycobacterial. If rifampicin is essential, increase the relugolix dose as directed in labeling and monitor response.
What other medicines interact with Rifampicin?
MediHelp also lists interactions of Rifampicin with, for example, Cabotegravir, Delamanid, Doravirine. The full list is on the Rifampicin page.
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