Drug interactions
Remifentanil + Sertraline
Severity: Moderate
Remifentanil and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioid and SSRI co-therapy can increase the risk of serotonin syndrome. Reports with remifentanil are rare, but the outcome can be serious.
What this interaction means in plain words
Remifentanil and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Remifentanil belongs to Musculoskeletal; Sertraline belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from SSRI reuptake inhibition and opioid activity.
What to do
Monitor for clonus, agitation, hyperthermia and autonomic instability. Stop serotonergic drugs and give supportive care if serotonin syndrome occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Remifentanil with Sertraline?
MediHelp rates the interaction as moderate. Remifentanil and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioid and SSRI co-therapy can increase the risk of serotonin syndrome. Reports with remifentanil are rare, but the outcome can be serious.
How serious is the interaction between Remifentanil and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clonus, agitation, hyperthermia and autonomic instability. Stop serotonergic drugs and give supportive care if serotonin syndrome occurs.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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