Drug interactions
Remimazolam + Ziprasidone
Severity: Major
Remimazolam and Ziprasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam is a short-acting benzodiazepine sedative and ziprasidone also causes sedation. Together they can produce deeper than intended sedation and respiratory depression.
What this interaction means in plain words
Remimazolam and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Remimazolam belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive central nervous system depression via GABA-A potentiation and antipsychotic sedative effects.
What to do
Titrate remimazolam carefully, using lower doses if needed. Continuously monitor oxygen saturation, respiration and blood pressure through the procedure and recovery.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Remimazolam
Frequently asked questions
Can I take Remimazolam with Ziprasidone?
MediHelp rates the interaction as major. Remimazolam and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Remimazolam is a short-acting benzodiazepine sedative and ziprasidone also causes sedation. Together they can produce deeper than intended sedation and respiratory depression.
How serious is the interaction between Remimazolam and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully, using lower doses if needed. Continuously monitor oxygen saturation, respiration and blood pressure through the procedure and recovery.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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