Drug interactions
Repaglinide + Rifampin
Severity: Moderate
Repaglinide and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces CYP3A4 and CYP2C8, lowering repaglinide exposure and its glucose-lowering effect. Hypoglycemia can occur if rifampin is stopped while the dose has been raised.
What this interaction means in plain words
Repaglinide and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces CYP3A4 and CYP2C8, increasing repaglinide clearance.
What to do
Monitor blood glucose and adjust the repaglinide dose when starting or stopping rifampin. Reduce the dose again after rifampin discontinuation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Rifampin?
MediHelp rates the interaction as moderate. Repaglinide and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces CYP3A4 and CYP2C8, lowering repaglinide exposure and its glucose-lowering effect. Hypoglycemia can occur if rifampin is stopped while the dose has been raised.
How serious is the interaction between Repaglinide and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and adjust the repaglinide dose when starting or stopping rifampin. Reduce the dose again after rifampin discontinuation.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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