Drug interactions
Repaglinide + Ropeginterferon alfa 2b
Severity: Minor
Repaglinide and Ropeginterferon alfa 2b: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Interferons can suppress CYP450 activity and may raise exposure to CYP substrates such as repaglinide. Interferons can also alter glucose homeostasis, so glycemic control may change.
What this interaction means in plain words
Repaglinide and Ropeginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cytokine-mediated suppression of CYP450 enzymes may reduce repaglinide metabolism; the effect is not well quantified.
What to do
Monitor blood glucose after starting ropeginterferon and adjust repaglinide if hypoglycemia or hyperglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Ropeginterferon alfa 2b?
MediHelp rates the interaction as minor. Repaglinide and Ropeginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Interferons can suppress CYP450 activity and may raise exposure to CYP substrates such as repaglinide. Interferons can also alter glucose homeostasis, so glycemic control may change.
How serious is the interaction between Repaglinide and Ropeginterferon alfa 2b?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting ropeginterferon and adjust repaglinide if hypoglycemia or hyperglycemia occurs.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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