Drug interactions
Repaglinide + Sacubitril / valsartan
Severity: Minor
Repaglinide and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide may inhibit OATP1B1 and could slightly increase valsartan exposure, but this is based on in vitro data and is unlikely to be clinically important. Both drugs can lower blood glucose or blood pressure independently, so no meaningful combined effect is expected.
What this interaction means in plain words
Repaglinide and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible OATP1B1 inhibition by repaglinide may reduce hepatic uptake of valsartan; clinical relevance is unproven.
What to do
No dose adjustment is required; monitor blood pressure and blood glucose as part of routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Repaglinide and Sacubitril / valsartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Repaglinide and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Repaglinide may inhibit OATP1B1 and could slightly increase valsartan exposure, but this is based on in vitro data and is unlikely to be clinically important. Both drugs can lower blood glucose or blood pressure independently, so no meaningful combined effect is expected.
How serious is the interaction between Repaglinide and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor blood pressure and blood glucose as part of routine care.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
