Drug interactions
Repaglinide + Sage
Severity: Minor
Repaglinide and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sage extracts have shown glucose-lowering effects in some animal and small human studies. Taken with repaglinide, additive hypoglycemia is possible, especially with concentrated products.
What this interaction means in plain words
Repaglinide and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hypoglycemic activity of sage constituents; the mechanism is incompletely characterized.
What to do
Monitor blood glucose in patients using sage supplements or teas regularly. Reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Sage?
MediHelp rates the interaction as minor. Repaglinide and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sage extracts have shown glucose-lowering effects in some animal and small human studies. Taken with repaglinide, additive hypoglycemia is possible, especially with concentrated products.
How serious is the interaction between Repaglinide and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose in patients using sage supplements or teas regularly. Reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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