Drug interactions
Repaglinide + Saquinavir
Severity: Moderate
Repaglinide and Saquinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir, a ritonavir-boosted protease inhibitor, can raise repaglinide exposure by inhibiting its CYP3A4-mediated metabolism. Higher repaglinide levels may cause prolonged or excessive blood glucose lowering and hypoglycemia.
What this interaction means in plain words
Repaglinide and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Saquinavir (usually ritonavir-boosted) inhibits intestinal and hepatic CYP3A4, reducing repaglinide clearance.
What to do
Monitor blood glucose closely when starting or stopping saquinavir and reduce the repaglinide dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Saquinavir?
MediHelp rates the interaction as moderate. Repaglinide and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saquinavir, a ritonavir-boosted protease inhibitor, can raise repaglinide exposure by inhibiting its CYP3A4-mediated metabolism. Higher repaglinide levels may cause prolonged or excessive blood glucose lowering and hypoglycemia.
How serious is the interaction between Repaglinide and Saquinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping saquinavir and reduce the repaglinide dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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