Drug interactions
Repaglinide + Sofosbuvir / velpatasvir
Severity: Moderate
Repaglinide and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits hepatic uptake transporters such as OATP1B1, which contribute to repaglinide hepatic uptake. Repaglinide exposure may therefore increase, raising the risk of hypoglycemia.
What this interaction means in plain words
Repaglinide and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Velpatasvir inhibits OATP1B1/1B3 transporters, reducing hepatic uptake and clearance of repaglinide.
What to do
Monitor blood glucose during co-administration and reduce the repaglinide dose if hypoglycemia occurs. Also reassess glycemic control as hepatitis C is treated, since glucose levels may change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Repaglinide and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir inhibits hepatic uptake transporters such as OATP1B1, which contribute to repaglinide hepatic uptake. Repaglinide exposure may therefore increase, raising the risk of hypoglycemia.
How serious is the interaction between Repaglinide and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during co-administration and reduce the repaglinide dose if hypoglycemia occurs. Also reassess glycemic control as hepatitis C is treated, since glucose levels may change.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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