Drug interactions
Repaglinide + Somatropin
Severity: Moderate
Repaglinide and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatropin reduces insulin sensitivity and may raise blood glucose, weakening the effect of repaglinide. It might also modestly increase CYP3A4 clearance of repaglinide.
What this interaction means in plain words
Repaglinide and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Somatropin belongs to Endocrine.
Why it happens
Growth hormone-induced insulin resistance opposes the antidiabetic effect, with possible CYP3A4 induction.
What to do
Monitor blood glucose and HbA1c after starting or changing the somatropin dose, and raise the repaglinide dose or add therapy as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Somatropin?
MediHelp rates the interaction as moderate. Repaglinide and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatropin reduces insulin sensitivity and may raise blood glucose, weakening the effect of repaglinide. It might also modestly increase CYP3A4 clearance of repaglinide.
How serious is the interaction between Repaglinide and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the somatropin dose, and raise the repaglinide dose or add therapy as required.
What other medicines interact with Somatropin?
MediHelp also lists interactions of Somatropin with, for example, Acarbose, Albiglutide, Alogliptin-metformin. The full list is on the Somatropin page.
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