Drug interactions
Repaglinide + Sulfamethoxazole
Severity: Moderate
Repaglinide and Sulfamethoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole, usually combined with trimethoprim, has been associated with hypoglycemia in patients on antidiabetic drugs. Trimethoprim in the combination inhibits CYP2C8 and may raise repaglinide levels.
What this interaction means in plain words
Repaglinide and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfamethoxazole may add to glucose lowering, and the trimethoprim component inhibits CYP2C8-mediated repaglinide metabolism.
What to do
Monitor blood glucose during the antibiotic course and warn the patient about hypoglycemia. Reduce the repaglinide dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Sulfamethoxazole?
MediHelp rates the interaction as moderate. Repaglinide and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfamethoxazole, usually combined with trimethoprim, has been associated with hypoglycemia in patients on antidiabetic drugs. Trimethoprim in the combination inhibits CYP2C8 and may raise repaglinide levels.
How serious is the interaction between Repaglinide and Sulfamethoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the antibiotic course and warn the patient about hypoglycemia. Reduce the repaglinide dose if glucose falls.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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