Drug interactions
Repaglinide + Sulfamethoxypyridazine
Severity: Moderate
Repaglinide and Sulfamethoxypyridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-acting sulfonamides can potentiate the hypoglycemic effect of antidiabetic drugs, so combination with repaglinide may increase hypoglycemia risk. The data are limited and mostly extrapolated from other sulfonamides.
What this interaction means in plain words
Repaglinide and Sulfamethoxypyridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive glucose lowering through enhanced insulin secretion; the mechanism is not well established.
What to do
Monitor blood glucose when the sulfonamide is started or stopped. Lower the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Sulfamethoxypyridazine?
MediHelp rates the interaction as moderate. Repaglinide and Sulfamethoxypyridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Long-acting sulfonamides can potentiate the hypoglycemic effect of antidiabetic drugs, so combination with repaglinide may increase hypoglycemia risk. The data are limited and mostly extrapolated from other sulfonamides.
How serious is the interaction between Repaglinide and Sulfamethoxypyridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when the sulfonamide is started or stopped. Lower the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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