Drug interactions
Repaglinide + Topiramate
Severity: Minor
Repaglinide and Topiramate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide is metabolised by CYP2C8 and CYP3A4, so inducers may lower exposure and weaken glucose control. Topiramate is only a weak inducer, so any effect is expected to be small.
What this interaction means in plain words
Repaglinide and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Repaglinide belongs to Endocrine; Topiramate belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by topiramate may modestly increase repaglinide clearance.
What to do
Monitor blood glucose after starting or stopping topiramate and titrate repaglinide to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Topiramate
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Topiramate?
MediHelp rates the interaction as minor. Repaglinide and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Repaglinide is metabolised by CYP2C8 and CYP3A4, so inducers may lower exposure and weaken glucose control. Topiramate is only a weak inducer, so any effect is expected to be small.
How serious is the interaction between Repaglinide and Topiramate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping topiramate and titrate repaglinide to response.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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