Drug interactions
Repaglinide + Xipamide
Severity: Minor
Repaglinide and Xipamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-like diuretics such as xipamide can impair glucose tolerance and may weaken the effect of antidiabetic drugs. Repaglinide is cleared mainly by metabolism, so increased renal clearance is not a credible mechanism.
What this interaction means in plain words
Repaglinide and Xipamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Diuretic-related impairment of glucose tolerance, possibly via hypokalemia and reduced insulin secretion, opposes repaglinide.
What to do
Monitor blood glucose and serum potassium after starting xipamide. Adjust repaglinide if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Xipamide?
MediHelp rates the interaction as minor. Repaglinide and Xipamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide-like diuretics such as xipamide can impair glucose tolerance and may weaken the effect of antidiabetic drugs. Repaglinide is cleared mainly by metabolism, so increased renal clearance is not a credible mechanism.
How serious is the interaction between Repaglinide and Xipamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium after starting xipamide. Adjust repaglinide if control worsens.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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