Drug interactions
Reteplase + Sulindac
Severity: Major
Reteplase and Sulindac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reteplase is a thrombolytic that substantially raises bleeding risk, and sulindac impairs platelet function and can injure the gastric mucosa. The combination may increase serious hemorrhage.
What this interaction means in plain words
Reteplase and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive effects on hemostasis: fibrinolysis plus NSAID platelet inhibition.
What to do
Avoid starting sulindac around thrombolytic therapy; if an NSAID has been taken, monitor closely for bleeding and weigh risks before thrombolysis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Reteplase with Sulindac?
MediHelp rates the interaction as major. Reteplase and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Reteplase is a thrombolytic that substantially raises bleeding risk, and sulindac impairs platelet function and can injure the gastric mucosa. The combination may increase serious hemorrhage.
How serious is the interaction between Reteplase and Sulindac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting sulindac around thrombolytic therapy; if an NSAID has been taken, monitor closely for bleeding and weigh risks before thrombolysis.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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