Drug interactions
Rifabutin + Sorafenib
Severity: Moderate
Rifabutin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin is a CYP3A4 inducer and may lower sorafenib exposure, which could reduce its antitumor efficacy. The inducing effect of rifabutin is weaker than that of rifampin, and the clinical impact on sorafenib is likely modest.
What this interaction means in plain words
Rifabutin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifabutin belongs to Anti Bacterial; Sorafenib belongs to Oncology.
Why it happens
Rifabutin induces CYP3A4, increasing the metabolism of sorafenib.
What to do
Consider an alternative to rifabutin if feasible. Monitor tumor response and consider whether a sorafenib dose increase is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Rifabutin with Sorafenib?
MediHelp rates the interaction as moderate. Rifabutin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin is a CYP3A4 inducer and may lower sorafenib exposure, which could reduce its antitumor efficacy. The inducing effect of rifabutin is weaker than that of rifampin, and the clinical impact on sorafenib is likely modest.
How serious is the interaction between Rifabutin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative to rifabutin if feasible. Monitor tumor response and consider whether a sorafenib dose increase is needed.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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