Drug interactions
Rifabutin + Vincristine
Severity: Moderate
Rifabutin and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and can accelerate vincristine clearance, potentially reducing its effect. Rifabutin is a weaker inducer than rifampicin, so the effect is likely smaller.
What this interaction means in plain words
Rifabutin and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifabutin belongs to Anti Bacterial; Vincristine belongs to Oncology.
Why it happens
Rifabutin induces CYP3A4 and increases the metabolism of vincristine.
What to do
Monitor for reduced therapeutic response to vincristine. Where possible choose a non-inducing alternative for the indication.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Rifabutin with Vincristine?
MediHelp rates the interaction as moderate. Rifabutin and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4 and can accelerate vincristine clearance, potentially reducing its effect. Rifabutin is a weaker inducer than rifampicin, so the effect is likely smaller.
How serious is the interaction between Rifabutin and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced therapeutic response to vincristine. Where possible choose a non-inducing alternative for the indication.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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