Drug interactions
Rifabutin + Vinorelbine
Severity: Moderate
Rifabutin and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and may lower vinorelbine exposure, potentially reducing efficacy. The induction is weaker than with rifampicin.
What this interaction means in plain words
Rifabutin and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifabutin belongs to Anti Bacterial; Vinorelbine belongs to Oncology.
Why it happens
CYP3A4 induction by rifabutin increases vinorelbine metabolism.
What to do
Monitor tumor response and consider an alternative antimycobacterial agent if feasible; avoid empirical dose escalation of vinorelbine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Rifabutin with Vinorelbine?
MediHelp rates the interaction as moderate. Rifabutin and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4 and may lower vinorelbine exposure, potentially reducing efficacy. The induction is weaker than with rifampicin.
How serious is the interaction between Rifabutin and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and consider an alternative antimycobacterial agent if feasible; avoid empirical dose escalation of vinorelbine.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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