Drug interactions
Rifampin + Saxagliptin-metformin
Severity: Moderate
Rifampin and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces CYP3A4 and lowers saxagliptin exposure, particularly of the parent drug, though the active metabolite is less affected. The overall effect on glycemic control is usually modest.
What this interaction means in plain words
Rifampin and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction increases saxagliptin metabolism.
What to do
Monitor glycemic control and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Rifampin with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Rifampin and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces CYP3A4 and lowers saxagliptin exposure, particularly of the parent drug, though the active metabolite is less affected. The overall effect on glycemic control is usually modest.
How serious is the interaction between Rifampin and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and adjust antidiabetic therapy if needed.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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