Drug interactions
Rifampin + Secobarbital
Severity: Moderate
Rifampin and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a potent enzyme inducer and can increase the clearance of barbiturates, shortening and weakening their effect. Hypnotic or anticonvulsant efficacy may fall.
What this interaction means in plain words
Rifampin and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of hepatic CYP enzymes by rifampin increases secobarbital metabolism.
What to do
Monitor clinical response and increase the secobarbital dose if needed; reassess dosing after rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Rifampin with Secobarbital?
MediHelp rates the interaction as moderate. Rifampin and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a potent enzyme inducer and can increase the clearance of barbiturates, shortening and weakening their effect. Hypnotic or anticonvulsant efficacy may fall.
How serious is the interaction between Rifampin and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the secobarbital dose if needed; reassess dosing after rifampin is stopped.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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