Drug interactions
Rifampin + Tamsulosin
Severity: Moderate
Rifampin and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a potent enzyme inducer and can reduce tamsulosin concentrations. Lower exposure may lead to loss of symptom relief.
What this interaction means in plain words
Rifampin and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces CYP3A4 (and CYP2D6 to some degree), increasing tamsulosin metabolism.
What to do
Monitor urinary symptoms and consider increasing the tamsulosin dose or switching agents. Reassess when rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Frequently asked questions
Can I take Rifampin with Tamsulosin?
MediHelp rates the interaction as moderate. Rifampin and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a potent enzyme inducer and can reduce tamsulosin concentrations. Lower exposure may lead to loss of symptom relief.
How serious is the interaction between Rifampin and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptoms and consider increasing the tamsulosin dose or switching agents. Reassess when rifampin is stopped.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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