Drug interactions
Rifampin + Tinidazole
Severity: Moderate
Rifampin and Tinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin strongly induces CYP3A4 and substantially increases tinidazole clearance, lowering its exposure. This can lead to subtherapeutic levels and failure of treatment.
What this interaction means in plain words
Rifampin and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces hepatic and intestinal CYP3A4, accelerating tinidazole metabolism.
What to do
Avoid the combination where possible or monitor closely for treatment failure. Consider an alternative antimicrobial or dose adjustment if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Frequently asked questions
Can I take Rifampin with Tinidazole?
MediHelp rates the interaction as moderate. Rifampin and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin strongly induces CYP3A4 and substantially increases tinidazole clearance, lowering its exposure. This can lead to subtherapeutic levels and failure of treatment.
How serious is the interaction between Rifampin and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible or monitor closely for treatment failure. Consider an alternative antimicrobial or dose adjustment if needed.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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