Drug interactions
Rifampin + Vardenafil
Severity: Moderate
Rifampin and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces CYP3A4 and can substantially reduce vardenafil concentrations. This may lead to loss of erectile efficacy.
What this interaction means in plain words
Rifampin and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 metabolism of vardenafil by rifampin, lowering exposure.
What to do
Expect reduced response and consider an alternative to vardenafil. Do not routinely raise the dose beyond the labeled maximum.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Rifampin with Vardenafil?
MediHelp rates the interaction as moderate. Rifampin and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces CYP3A4 and can substantially reduce vardenafil concentrations. This may lead to loss of erectile efficacy.
How serious is the interaction between Rifampin and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Expect reduced response and consider an alternative to vardenafil. Do not routinely raise the dose beyond the labeled maximum.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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