Drug interactions
rifampin + warfarin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↓ INR → thrombosis risk.
Mechanism of action
Potent CYP induction.
Clinical management
Substantial warfarin dose increase; intensive INR monitoring.
Drug reference
References
Frequently asked questions
Can I take rifampin with warfarin?
The interaction is rated: Major. ↓ INR → thrombosis risk.
How serious is the interaction between rifampin and warfarin?
The interaction is rated: Major. Evidence level: High.
How is the interaction between rifampin and warfarin managed?
Substantial warfarin dose increase; intensive INR monitoring.
Why do rifampin and warfarin interact?
Potent CYP induction.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.