Drug interactions
Rifapentine + Zolpidem
Severity: Moderate
Rifapentine and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4 and can substantially reduce zolpidem exposure, as seen with rifampin, leading to loss of hypnotic effect. The effect may persist for some time after the rifamycin is stopped.
What this interaction means in plain words
Rifapentine and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifapentine belongs to Anti Bacterial; Zolpidem belongs to Central Nervous System.
Why it happens
Rifapentine induction of CYP3A4 increases zolpidem metabolic clearance.
What to do
Monitor for reduced hypnotic efficacy and consider a non-CYP3A4-dependent sleep option if response is inadequate; avoid exceeding the maximum labeled zolpidem dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Rifapentine with Zolpidem?
MediHelp rates the interaction as moderate. Rifapentine and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces CYP3A4 and can substantially reduce zolpidem exposure, as seen with rifampin, leading to loss of hypnotic effect. The effect may persist for some time after the rifamycin is stopped.
How serious is the interaction between Rifapentine and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced hypnotic efficacy and consider a non-CYP3A4-dependent sleep option if response is inadequate; avoid exceeding the maximum labeled zolpidem dose.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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