Drug interactions
Rifaximin + Sarecycline
Severity: Minor
Rifaximin and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline has been described as a weak P-glycoprotein inhibitor and might modestly raise rifaximin exposure. Because rifaximin is minimally absorbed, the clinical impact is expected to be small.
What this interaction means in plain words
Rifaximin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rifaximin belongs to Anti Bacterial; Sarecycline belongs to Anti Bacterial.
Why it happens
Possible weak P-glycoprotein inhibition by sarecycline reduces rifaximin efflux.
What to do
No dose adjustment is needed. Be alert for rifaximin adverse effects in patients with severe hepatic impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rifaximin
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporine + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Rifaximin with Sarecycline?
MediHelp rates the interaction as minor. Rifaximin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline has been described as a weak P-glycoprotein inhibitor and might modestly raise rifaximin exposure. Because rifaximin is minimally absorbed, the clinical impact is expected to be small.
How serious is the interaction between Rifaximin and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Be alert for rifaximin adverse effects in patients with severe hepatic impairment.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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