Drug interactions
Riociguat + Ulipristal
Severity: Moderate
Riociguat and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ulipristal is a CYP3A4 substrate with some inhibitory activity, and riociguat is cleared partly by CYP3A. Any rise in riociguat exposure could cause symptomatic hypotension, though the effect of ulipristal on riociguat is predicted and not well documented.
What this interaction means in plain words
Riociguat and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible weak inhibition of CYP3A-mediated riociguat metabolism by ulipristal, a predicted pharmacokinetic interaction.
What to do
Monitor blood pressure and symptoms of hypotension when ulipristal is given to a patient on riociguat. Reduce the riociguat dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Riociguat with Ulipristal?
MediHelp rates the interaction as moderate. Riociguat and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ulipristal is a CYP3A4 substrate with some inhibitory activity, and riociguat is cleared partly by CYP3A. Any rise in riociguat exposure could cause symptomatic hypotension, though the effect of ulipristal on riociguat is predicted and not well documented.
How serious is the interaction between Riociguat and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when ulipristal is given to a patient on riociguat. Reduce the riociguat dose if hypotension develops.
What other medicines interact with Riociguat?
MediHelp also lists interactions of Riociguat with, for example, Avanafil, Dipyridamole, Isosorbide dinitrate. The full list is on the Riociguat page.
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