Drug interactions
ritonavir + sildenafil
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ sildenafil exposure → hypotension/AE.
Mechanism of action
Strong CYP3A4 inhibition.
Clinical management
Use lowest doses or avoid; observe label limits.
Drug reference
References
Frequently asked questions
Can I take ritonavir with sildenafil?
The interaction is rated: Major. ↑ sildenafil exposure → hypotension/AE.
How serious is the interaction between ritonavir and sildenafil?
The interaction is rated: Major. Evidence level: High.
How is the interaction between ritonavir and sildenafil managed?
Use lowest doses or avoid; observe label limits.
Why do ritonavir and sildenafil interact?
Strong CYP3A4 inhibition.
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