Drug interactions
Ritonavir + Tenofovir disoproxil
Severity: Moderate
Ritonavir and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted regimens can modestly raise tenofovir exposure, and kidney tubular toxicity may be more likely. Immune reconstitution syndrome is a general consequence of ART, not specific to this pair.
What this interaction means in plain words
Ritonavir and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ritonavir may inhibit intestinal P-glycoprotein and renal transporters, raising tenofovir exposure.
What to do
Monitor renal function, phosphate and urinary protein at baseline and periodically; no routine dose change is needed with normal renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Ritonavir and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted regimens can modestly raise tenofovir exposure, and kidney tubular toxicity may be more likely. Immune reconstitution syndrome is a general consequence of ART, not specific to this pair.
How serious is the interaction between Ritonavir and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, phosphate and urinary protein at baseline and periodically; no routine dose change is needed with normal renal function.
What other medicines interact with Ritonavir?
MediHelp also lists interactions of Ritonavir with, for example, Alfuzosin, Amiodarone, Avanafil. The full list is on the Ritonavir page.
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