Drug interactions
Rituximab + Ublituximab
Severity: Major
Rituximab and Ublituximab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are anti-CD20 antibodies that deplete B cells, so combining them duplicates therapy and increases the risk of serious infection, hypogammaglobulinemia and prolonged cytopenias. There is no established benefit from using both.
What this interaction means in plain words
Rituximab and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rituximab belongs to Musculoskeletal; Ublituximab belongs to Miscellaneous.
Why it happens
Duplicate anti-CD20 B-cell depletion producing additive immunosuppression.
What to do
Avoid using both together and choose one anti-CD20 agent. When switching, review B-cell recovery and immunoglobulin levels and monitor for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rituximab
Other interactions of Ublituximab
Frequently asked questions
Can I take Rituximab with Ublituximab?
MediHelp rates the interaction as major. Rituximab and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are anti-CD20 antibodies that deplete B cells, so combining them duplicates therapy and increases the risk of serious infection, hypogammaglobulinemia and prolonged cytopenias. There is no established benefit from using both.
How serious is the interaction between Rituximab and Ublituximab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both together and choose one anti-CD20 agent. When switching, review B-cell recovery and immunoglobulin levels and monitor for infection.
What other medicines interact with Rituximab?
MediHelp also lists interactions of Rituximab with, for example, Adenovirus types 4 and 7 live, Baricitinib, Certolizumab pegol. The full list is on the Rituximab page.
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