Drug interactions
Rivastigmine + Sulindac
Severity: Moderate
Rivastigmine and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholinesterase inhibitors increase gastric acid secretion and may raise the risk of ulcers and GI bleeding, which can be compounded by NSAIDs. The risk is mainly in patients with other ulcer risk factors.
What this interaction means in plain words
Rivastigmine and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rivastigmine belongs to Central Nervous System; Sulindac belongs to Musculoskeletal.
Why it happens
Cholinergic stimulation of gastric acid secretion combined with NSAID-mediated loss of mucosal prostaglandin protection.
What to do
Monitor for symptoms of active or occult GI bleeding, and consider gastroprotection in patients at higher risk. Avoid prolonged NSAID courses where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Rivastigmine
Frequently asked questions
Can I take Rivastigmine with Sulindac?
MediHelp rates the interaction as moderate. Rivastigmine and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholinesterase inhibitors increase gastric acid secretion and may raise the risk of ulcers and GI bleeding, which can be compounded by NSAIDs. The risk is mainly in patients with other ulcer risk factors.
How serious is the interaction between Rivastigmine and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for symptoms of active or occult GI bleeding, and consider gastroprotection in patients at higher risk. Avoid prolonged NSAID courses where possible.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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