Drug interactions
Rocuronium + Streptomycin
Severity: Major
Rocuronium and Streptomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Streptomycin can intensify and prolong neuromuscular blockade from rocuronium. Delayed recovery, respiratory depression or apnea may occur.
What this interaction means in plain words
Rocuronium and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rocuronium belongs to Musculoskeletal; Streptomycin belongs to Anti Bacterial.
Why it happens
Aminoglycosides inhibit presynaptic acetylcholine release and reduce postsynaptic sensitivity, adding to competitive nicotinic blockade.
What to do
Use train-of-four monitoring and reduce rocuronium dosing as needed. Keep ventilatory support available until full neuromuscular recovery.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rocuronium
Other interactions of Streptomycin
Frequently asked questions
Can I take Rocuronium with Streptomycin?
MediHelp rates the interaction as major. Rocuronium and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Streptomycin can intensify and prolong neuromuscular blockade from rocuronium. Delayed recovery, respiratory depression or apnea may occur.
How serious is the interaction between Rocuronium and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use train-of-four monitoring and reduce rocuronium dosing as needed. Keep ventilatory support available until full neuromuscular recovery.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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