Drug interactions
Romidepsin + Sertraline
Severity: Moderate
Romidepsin and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin has been linked to ECG changes including QT prolongation, and sertraline adds a modest QT effect. Together they may increase the risk of arrhythmia, especially with electrolyte abnormalities.
What this interaction means in plain words
Romidepsin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarisation.
What to do
Check ECG and correct potassium and magnesium before and during romidepsin cycles. Consider an alternative antidepressant if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Romidepsin with Sertraline?
MediHelp rates the interaction as moderate. Romidepsin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin has been linked to ECG changes including QT prolongation, and sertraline adds a modest QT effect. Together they may increase the risk of arrhythmia, especially with electrolyte abnormalities.
How serious is the interaction between Romidepsin and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium before and during romidepsin cycles. Consider an alternative antidepressant if QTc becomes prolonged.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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