Drug interactions
Romidepsin + Umeclidinium-vilanterol
Severity: Moderate
Romidepsin and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin can cause QT changes and electrolyte disturbances, and vilanterol may add to cardiac effects and lower potassium. The combination may raise the risk of arrhythmia.
What this interaction means in plain words
Romidepsin and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and beta-2 agonist-related hypokalemia.
What to do
Monitor ECG, potassium and magnesium during romidepsin therapy and correct abnormalities before each dose. Consider alternatives to the beta-agonist if QT prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Frequently asked questions
Can I take Romidepsin with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Romidepsin and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin can cause QT changes and electrolyte disturbances, and vilanterol may add to cardiac effects and lower potassium. The combination may raise the risk of arrhythmia.
How serious is the interaction between Romidepsin and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and magnesium during romidepsin therapy and correct abnormalities before each dose. Consider alternatives to the beta-agonist if QT prolongation develops.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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