Drug interactions
Romidepsin + Verapamil
Severity: Moderate
Romidepsin and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP3A4 and P-glycoprotein and may raise romidepsin exposure, increasing hematologic and gastrointestinal toxicity. Romidepsin also carries QT/ECG change risks.
What this interaction means in plain words
Romidepsin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Verapamil inhibits CYP3A4 and P-gp, reducing the clearance of romidepsin.
What to do
Monitor blood counts, electrolytes and ECG during romidepsin therapy. Consider an alternative to verapamil where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Romidepsin with Verapamil?
MediHelp rates the interaction as moderate. Romidepsin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits CYP3A4 and P-glycoprotein and may raise romidepsin exposure, increasing hematologic and gastrointestinal toxicity. Romidepsin also carries QT/ECG change risks.
How serious is the interaction between Romidepsin and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, electrolytes and ECG during romidepsin therapy. Consider an alternative to verapamil where possible.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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