Drug interactions
Romidepsin + Vinblastine
Severity: Minor
Romidepsin and Vinblastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin is a P-glycoprotein substrate, and the effect of vinblastine on its exposure is not clearly established. A clinically meaningful change in either drug is uncertain, though additive myelosuppression is possible.
What this interaction means in plain words
Romidepsin and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition at P-glycoprotein efflux; the net effect is not well established.
What to do
Monitor blood counts during combined treatment and adjust doses based on toxicity or response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinblastine
Frequently asked questions
Can I take Romidepsin with Vinblastine?
MediHelp rates the interaction as minor. Romidepsin and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Romidepsin is a P-glycoprotein substrate, and the effect of vinblastine on its exposure is not clearly established. A clinically meaningful change in either drug is uncertain, though additive myelosuppression is possible.
How serious is the interaction between Romidepsin and Vinblastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts during combined treatment and adjust doses based on toxicity or response.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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